최현진

인사말

최현진교수

전문분야 | 신경약물학
전화번호 | 031-881-7168
E – mail | hjchoi3@cha.ac.kr

​학력

 

이화여자대학교 약학대학 약학과, 약학사
이화여자대학교 대학원 약학과, 석사 (약물학)
이화여자대학교 대학원 약학과, 박사 (약물 및 임상약학)

주요경력

국립독성연구원, 보건연구사
울산대학교 의과대학, PostDoc
울산대학교 의과대학, 연구교수
Harvard Medical School, Research Fellow
전남대학교 약학대학, 조교수/부교수
차 의과학대학교 약학대학 종합약학연구소, 소장
(현) 차 의과학대학교 약학대학, 부교수
(현) 차 의과학대학교 임상약학대학원, 겸임교수
(현) 차 의과학대학교 약학대학, 학과장

한국연구재단, 전문위원 (의약학)
(현) Archives of Pharmacal Research, Associate Editor
(현) 대한약학회, 회원위원회 위원장

 

​주요연구내용

1. 카테콜아민 신경계 분화 및 기능 조절 연구
2. 퇴행성 신경질환 기전 및 예방/치료의 약물학적 타겟 연구
3. 산화성 스트레스 등에 대한 생체방어능력 조절 약물 발굴 연구
4. 불안/우울장애 기전 및 치료전략 발굴 연구
5. 노화에 따른 정신신경계 기능 조절 기전 및 항노화 약물 개발 연구

 

 

​연구실소개

약물학 연구실에서는 카테콜아민 신경계를 중심으로 신경계 기능 조절과 관련 질병 매개 신호를 분자생물학, 세포생물학 및 질병 모델을 적용한 연구를 통해 규명하고, 이를 기반으로 신경계 기능 조절과 질병 예방/치료의 약물학적 타겟을 찾는 것을 목표로 하고 있습니다.

구체적으로, 대표적 퇴행성 신경질환의 하나인 파킨슨병의 발병 기작과 관련하여 산화성 스트레스와 같은 환경적 요인, alpha-synuclein, LRRK2 돌연변이와 같은 유전적 요인 등을 중심으로 신경계 기능, 생존, 및 행동 변화에 영향을 미치는 신호 연구를 진행하고 있으며, 천연물 유래 신규 물질들을 중심으로 도파민 신경계 기능 조절 및 질병 치료 물질로의 기능 연구를 수행하고 있습니다.

[​국외논문]

  • Park JY, Yun H, Jo J, Baek JY, Lee SC, Choi YJ, Shim JS, Choi HJ, Lee S, Kang KS*. Beneficial effects of Cirsium japonicum var. maackii on menopausal symptoms in ovariectomized rats. Food Funct. 9(4):2480-2489. (2018 Apr 25)
  • Sim J, Park H, Lim J, Yoon I, Lim C, An H, Yun H, Choi HJ, Suh YG*. Stereoselective Synthesis of 1,4,5-Tri-cis-guaiane Sesquiterpene: First Total Synthesis of (-)-Dendroside C Aglycon. Org Lett. 20(3):586-589 (2018 Feb 2)
  • Lim J, Bang Y, Choi JH, Han A, Kwon MS, Liu KH, Choi HJ*. LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice. J Neurosci. 38(7):1611-1621 (2018 Feb 14)
  • Kim S, Lim J, Bang Y, Moon J, Kwon MS, Hong JT, Jeon J, Seo H, Choi HJ*Alpha-Synuclein Suppresses Retinoic Acid-Induced Neuronal Differentiation by Targeting the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway. Mol Neurobiol. 55(2):1607-1619 (2018 Feb)
  • Park HS, Han A, Yeo HL, Park MJ, You MJ, Choi HJ, Hong CW, Lee SH, Kim SH, Kim B, Kwon MS*. Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression. Oncotarget. 8(42):72528-72543 (2017 Aug 3)
  • Kim J, Lim J, Kang BY, Jung K, Choi HJ*Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling. Neurochem Int. 105:11-20 (May 2017)
  • Park KTShon JCKim JEPark GHChoi HJ*Liu KH*. Sulfatides Primarily Exist in the Substantia Nigra Region of Mouse Brain Tissue. Lipids 52(2):179-187 (Feb 2017)
  • Bang Y, Kim K-S, Seol W, Choi HJ*. LRRK2 interferes with aggresome formation for autophagic clearance. Mol Cell Neurosci. 75:71-80 (2016 Jun)
  • Lee SH, Lee KY, Choi HJ, Kang BY*. Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4. Arch Pharm Res. 39(4):547-54 (2016 Apr)
  • Zheng M, Zhang X, Guo S, Zhang X, Choi HJ, Lee MY, Kim KM*. PKCbII inhibits the ubiquitination of b-arrestin2 in an autophosphorylation-dependent manner. FEBS Lett. 589(24 Pt B):3929-37 (2015 Dec)
  • Han A, Yeo H, Park MJ, Kim SH, Choi HJ, Hong CW, and Kwon MS*. IL-4/10 prevents stress vulnerability following imipramine discontinuation. J Neuroinflammation. 12(1):197 (2015 Oct)
  • Lee SH, Cho YC, Kim KH, Lee IS, Choi HJ, Kang BY*. Artesunate inhibits proliferation of naïve CD4+ T cells but enhances function of effector T cells. Arch Pharm Res. 2015 38(6):1195-203 (2015 Jun)
  • Lim J, Choi HS, Choi HJ*Estrogen-related receptor gamma regulates dopaminergic neuronal phenotype by activating GSK3β/NFAT signaling in SH-SY5Y cells. J Neurochem. 133(4):544-57 (2015 May)
  • Lim J, Kim HI, Bang Y, Seol W, Choi HS, Choi HJ*Hypoxia-inducible factor-1α upregulates tyrosine hydroxylase and dopamine transporter by nuclear receptor ERRγ in SH-SY5Y cells. Neuroreport. 26(6):380-6 (2015 Apr)
  • Kim S, Park JM, Moon J, Choi HJ*. Alpha-synuclein interferes with cAMP/PKA-dependent upregulation of dopamine β-hydroxylase and is associated with abnormal adaptive responses to immobilization stress. Exp Neurol. 252:63-74 (2014)
  • Bang Y, Kang BY, Choi HJ*. Preconditioning stimulus of proteasome inhibitor enhances aggresome formation and autophagy in differentiated SH-SY5Y cells. Neurosci Lett. 566:263-8 (2014)
  • Lim J, Lee SH, Cho S, Lee IS, Kang BY, Choi HJ*. 4-Methoxychalcone enhances cisplatin-induced oxidative stress and cytotoxicity by inhibiting the Nrf2/ARE-mediated defense mechanism in A549 lung cancer cells. Mol Cells. 36(4):340-6 (2013)
  • Gal J, Bang Y, Choi HJ*. SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition. Neurochem Int. 61(7):992-1000. (2012)
  • Kim SS, Lim J, Bang Y, Gal J, Lee S-U, Cho Y-C, Yoon G, Kang BY, Cheon SH, Choi HJ*. Licochalcone E activates Nrf2/antioxidant response element signaling pathway both in neuronal and microglial cells: Therapeutic relevance to neurodegenerative disease. J Nut Biochem. 23(10):1314-23. (2012)
  • Lee I-S, Ryu DK, Lim J, Kang BY, Choi HJ*. Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells. Neurosci Lett. 509(1):17-21. (2012)
  • Bang Y, Lim J, Kim SS, Jeong HM, Jung K-K, Kang I-H, Lee K-Y, and Choi HJ*. Aroclor1254 interferes with estrogen receptor-mediated neuroprotection against beta-amyloid toxicity in cholinergic SN56 cells. Neurochem Int. 59(5):582-90. (2011)
  • Kim SS, Moon KR, and Choi HJ*. Alpha-synuclein interferes with cAMP/PKA-dependent CREB signaling for tyrosine hydroxylase gene expression in SK-N-BE(2)C cells. Arch Pharm Res. 34(5):837-45. (2011)
  • Lee IS, Lim J, Gal J, Kang JC, Kim HJ, Kang BY, Choi HJ*. Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem Int. 58(2):153-60. (2011)
  • Hong SJ, Huh YH, Leung A, Choi HJ, Ding Y, Kang UJ, Yoo SH, Buettner R, Kim KS*. Transcription factor AP-2β regulates the neurotransmitter phenotype and maturation of chromaffin cells. Mol Cell Neurosci. 46(1):245-51. (2011)
  • Yoon NS, Cho Y, Lee SY, Choi HJ, Hwang O*. Inactivation of aconitase by tetrahydrobiopterin in dopaminergic cells: relevance to PD. Exp Neurobiol. 19(1):23-9. (2010)
  • Cho YC, Lee SH, Yoon G, Kim HS, Na JY, Choi HJ, Cho CW, Cheon SH, Kang BY*. Licochalcone E reduces chronic allergic contact dermatitis and inhibits IL-12p40 production through down-regulation of NF-kappa B. Int Immunopharmacol. 10(9):1119-26. (2010)
  • No H, Bang Y, Lim J, Kim SS, Choi HS, Choi HJ*. Involvement of induction and mitochondrial targeting of orphan nuclear receptor Nur77 in 6-OHDA-induced SH-SY5Y cell death. Neurochem Int. 56(4):620-626. (2010)
  • Yoon S, Cong WT, Bang Y, Lee SN, Yoon CS, Kwack SJ, Kang TS, Lee KY, Choi JK, Choi HJ*. Proteome response to ochratoxin A-induced apoptotic cell death in mouse hippocampal HT22 cells. Neurotoxicology. 30(4):666-76. (2009)
  • Lim JH, Kim SS, Boo DH, No H, Kang BY, Kim EM, Hwang O, and Choi HJ*. Protective effect of bromocriptine against BH4-induced Cath.a cell death involving up-regulation of antioxidant enzymes. Neurosci Lett. 451(3):185-9. (2009)
  • Choi JM, Kim HJ, Lee KY, Choi HJ, Lee IS, Kang BY*. Increased IL-2 production in T cells by xanthohumol through enhanced NF-AT and AP-1 activity. Int Immunopharmacol. 9(1):103-7. (2009)
  • Quan W, Kim JH, Albert PR, Choi HJ, Kim KM*. Roles of G protein and beta-arrestin in dopamine D2 receptor-mediated ERK activation. Biochem Biophys Res Commun. 377(2):705-9. (2008)
  • Han Y, Jin YH, Kim YJ, Kang BY, Choi HJ, Kim DW, Yeo CY, Lee KY*. Acetylation of Sirt2 by p300 attenuates its deacetylase activity. Biochem Biophys Res Commun. 375(4):576-80. (2008)
  • Lim JH, Kim KM, Kim SW, Hwang O, Choi HJ*. Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: Novel cytoprotective mechanism against oxidative damage. Pharmacol Res. 57(5):325-31. (2008)
  • Chae S-W, Kang BY, Hwang O, and Choi HJ*. Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells. Neurosci Lett. 436:205-209. (2008)
  • Hong SJ, Choi HJ, Hong S, Huh Y, Chae H, and Kim KS*. Transcription factor GATA-3 regulates the transcriptional activity of dopamine β-hydroxylase by interacting with Sp1 and AP4. Neurochem Res. 33(9):1821-31. (2008)
  • Cho Y-C, Kim HJ, Kim Y-J, Lee KY, Choi HJ, Lee I-S, Kang BY*. Differential anti-inflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages. Int Immunopharmacol. 8:567-573. (2008)
  • Le Thanh N, Van HT, Lee SH, Choi HJ, Lee KY, Kang BY, Cho WJ*. Application of coupling reaction between lithiated toluamide and benzonitrile for the synthesis of phenolic benzo[c]phenanthridine alkaloid, oxyterihanine. Arch Pharm Res. 31(1):6-9. (2008)

[저서]

약물학, 범문에듀케이션 (2015.03) (ISBN 979-11-85305-81-3)
신경정신약리학-뇌와 약물남용, 신일서적㈜ (2014.12) (ISBN 979-11-85615-15-8)
약물학, 제12판, 도서출판 신일북스 (2012.02) (ISBN 978-89-5702-301-3 93510)
약리학 정리와 시험, 도서출판 신일북스 (2012.03) (ISBN 978-89-5702-300-6 93510)